Selected publications from our work on translational control, ribosome biology, and immune cell function.
Key papers with brief annotations explaining their significance.
T Vatovec, AL Neehus, KJL Jackson, J Bohlen
Nature Immunology
Demonstrates that somatic CBL deficiency selectively impairs B cell development while sparing T cell function, revealing cell-type specific requirements for this E3 ubiquitin ligase.
J Bohlen, I Bagaric, T Vatovec, M Ogishi, JL Casanova, J Bustamante
Journal of Clinical Investigation
Reveals the molecular mechanism underlying autoinflammation in CBL-deficient patients, identifying constitutive ERK activation in monocytes as the driver of disease.
J Bohlen, Q Zhou, Q Philippot, J Bustamante, Q Zhang, JL Casanova
Cell
Landmark discovery showing that MCTS1 is required for JAK2 translation in human immune cells, explaining why MCTS1-deficient patients are susceptible to mycobacterial infections.
J Bohlen, M Roiuk, M Neff, AA Teleman
Nucleic Acids Research
Identifies PRRC2 proteins as novel regulators of translation initiation that promote leaky scanning, expanding our understanding of start codon selection.
J Bohlen, M Roiuk, AA Teleman
Nucleic Acids Research
Demonstrates that rpS6 phosphorylation has transcript-specific effects on translation efficiency depending on ORF length, challenging the view of global translation regulation.
J Bohlen, L Harbrecht, S Blanco, KC von Hohenberg, K Fenzl, G Kramer, B Bukau, AA Teleman
Nature Communications
Establishes that DENR facilitates ribosome recycling after uORF translation, enabling reinitiation at main ORFs including the stress-response transcription factor ATF4.
J Bohlen, K Fenzl, G Kramer, B Bukau, AA Teleman
Molecular Cell
Develops a novel method to track scanning 40S ribosomes, revealing that they remain tethered to the mRNA cap during scanning in human cells.
Complete list of publications, sorted by year.
T Vatovec, AL Neehus, KJL Jackson, J Bohlen
Nature Immunology
Demonstrates that somatic CBL deficiency selectively impairs B cell development while sparing T cell function, revealing cell-type specific requirements for this E3 ubiquitin ligase.
SF Ahmed, J Anand, W Zhang, L Buetow, L Rishi, L Mitchell, J Bohlen
Molecular Therapy
M Ogishi, K Kitaoka, KL Good-Jacobson, J Bohlen
Immunity
J Bohlen, I Bagaric, T Vatovec, M Ogishi, JL Casanova, J Bustamante
Journal of Clinical Investigation
Reveals the molecular mechanism underlying autoinflammation in CBL-deficient patients, identifying constitutive ERK activation in monocytes as the driver of disease.
CA Arango-Franco, M Ogishi, S Unger, J Bohlen
Journal of Clinical Investigation
A Gervais, C Le Floc'h, T Le Voyer, J Bohlen
Proceedings of the National Academy of Sciences U.S.A.
AA Arias, AL Neehus, M Ogishi, J Bohlen
Nature
C David, CA Arango-Franco, M Badonyi, J Bohlen
Journal of Experimental Medicine
JN Peel, R Yang, T Le Voyer, J Bohlen
Journal of Clinical Investigation
AL Neehus, B Carey, M Landekic, J Bohlen
Cell
J Bohlen, Q Zhou, Q Philippot, J Bustamante, Q Zhang, JL Casanova
Cell
Landmark discovery showing that MCTS1 is required for JAK2 translation in human immune cells, explaining why MCTS1-deficient patients are susceptible to mycobacterial infections.
J Bohlen, M Roiuk, M Neff, AA Teleman
Nucleic Acids Research
Identifies PRRC2 proteins as novel regulators of translation initiation that promote leaky scanning, expanding our understanding of start codon selection.
Q Philippot, M Ogishi, J Bohlen
Science Immunology
G Kerner, AL Neehus, Q Philippot, J Bohlen
Cell Genomics
J Rosain, AL Neehus, J Manry, J Bohlen
Cell
T Le Voyer, AV Parent, X Liu, J Bohlen
Nature
M Ogishi, R Yang, R Rodriguez, J Bohlen
Journal of Experimental Medicine
J Wang, BS Shin, C Alvarado, JR Kim, J Bohlen, TE Dever, JD Puglisi
Cell
S Wagner, J Bohlen, A Herrmannova
Nature Protocols
M Ogishi, AA Arias, R Yang, J Bohlen
Journal of Experimental Medicine
J Rosain, A Bernasconi, E Prieto, J Bohlen
Journal of Clinical Immunology
Q Zhang, D Matuozzo, J Le Pen, J Bohlen
Journal of Experimental Medicine
K Clemm von Hohenberg, S Müller, S Schleich, J Bohlen
Nature Communications
JI Øvrebø, MR Bradley-Gill, N Zielke, J Bohlen
Proceedings of the National Academy of Sciences U.S.A.
J Bohlen, M Roiuk, AA Teleman
Nucleic Acids Research
Demonstrates that rpS6 phosphorylation has transcript-specific effects on translation efficiency depending on ORF length, challenging the view of global translation regulation.
J Bohlen, L Harbrecht, S Blanco, KC von Hohenberg, K Fenzl, G Kramer, B Bukau, AA Teleman
Nature Communications
Establishes that DENR facilitates ribosome recycling after uORF translation, enabling reinitiation at main ORFs including the stress-response transcription factor ATF4.
J Bohlen, K Fenzl, G Kramer, B Bukau, AA Teleman
Molecular Cell
Develops a novel method to track scanning 40S ribosomes, revealing that they remain tethered to the mRNA cap during scanning in human cells.
A Sriram, J Bohlen, AA Teleman
EMBO Reports
YL Ahmed, S Schleich, J Bohlen
PLOS Biology
E Phillips, V Lang, J Bohlen
International Journal of Cancer
N Zielke, M van Straaten, J Bohlen, BA Edgar
Methods in Molecular Biology
For a complete and up-to-date list of publications, visit these external profiles.
